Development of preservative-free nanoparticles-based emulsions: Effects of NP surface properties and sterilization process.
Identifieur interne : 000071 ( France/Analysis ); précédent : 000070; suivant : 000072Development of preservative-free nanoparticles-based emulsions: Effects of NP surface properties and sterilization process.
Auteurs : Laura Rowenczyk [France] ; Céline Picard [France] ; Cécile Duclairoir-Poc [France] ; Nicolas Hucher [France] ; Nicole Orange [France] ; Marc Feuilloley [France] ; Michel Grisel [France]Source :
- International journal of pharmaceutics [ 1873-3476 ] ; 2016.
Abstract
Model emulsions were developed with or without commercial titanium dioxide nanoparticles (NP) carrying various surface treatments in order to get close physicochemical properties whatever the NP surface polarity (hydrophilic and hydrophobic). Rheology and texturometry highlighted that the macroscopic properties of the three formulated emulsions were similar. However, characterizations by optical microscopy, static light scattering and zetametry showed that their microstructures reflected the diversity of the incorporated NP surface properties. In order to use these model emulsions as tools for biological evaluations of the NP in use, they had to show the lowest initial microbiological charge and, specifically for the NP-free emulsion, the lowest bactericidal effect. Hence, formulae were developed preservative-free and a thermal sterilization step was conducted. Efficiency of the sterilization and its impact on the emulsion integrity were monitored. Results highlighted the effect of the NP surface properties: only the control emulsion and the emulsion containing hydrophilic NP fulfilled both requirements. To ensure the usability of these model emulsions as tools to evaluate the 'NP effect' on representative bacteria of the skin microflora (S. aureus and P. fluorescens), impact on the bacterial growth was measured on voluntary inoculated formulae.
DOI: 10.1016/j.ijpharm.2016.06.014
PubMed: 27286638
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000017
- to stream PubMed, to step Curation: 000017
- to stream PubMed, to step Checkpoint: 000017
- to stream Ncbi, to step Merge: 000550
- to stream Ncbi, to step Curation: 000550
- to stream Ncbi, to step Checkpoint: 000550
- to stream Main, to step Merge: 000072
- to stream Main, to step Curation: 000073
- to stream Main, to step Exploration: 000073
- to stream France, to step Extraction: 000071
Links to Exploration step
pubmed:27286638Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Development of preservative-free nanoparticles-based emulsions: Effects of NP surface properties and sterilization process.</title><author><name sortKey="Rowenczyk, Laura" sort="Rowenczyk, Laura" uniqKey="Rowenczyk L" first="Laura" last="Rowenczyk">Laura Rowenczyk</name><affiliation wicri:level="3"><nlm:affiliation>Normandie Univ, ULH, CNRS, URCOM, 76600 Le Havre, France; Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, 55 rue saint Germain 27000 Evreux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie Univ, ULH, CNRS, URCOM, 76600 Le Havre, France; Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, 55 rue saint Germain 27000 Evreux</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Evreux</settlement></placeName></affiliation></author><author><name sortKey="Picard, Celine" sort="Picard, Celine" uniqKey="Picard C" first="Céline" last="Picard">Céline Picard</name><affiliation wicri:level="3"><nlm:affiliation>Normandie Univ, ULH, CNRS, URCOM, 76600 Le Havre, France. Electronic address: celine.picard@univ-lehavre.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie Univ, ULH, CNRS, URCOM, 76600 Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Duclairoir Poc, Cecile" sort="Duclairoir Poc, Cecile" uniqKey="Duclairoir Poc C" first="Cécile" last="Duclairoir-Poc">Cécile Duclairoir-Poc</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, 55 rue saint Germain 27000 Evreux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, 55 rue saint Germain 27000 Evreux</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Evreux</settlement></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Hucher, Nicolas" sort="Hucher, Nicolas" uniqKey="Hucher N" first="Nicolas" last="Hucher">Nicolas Hucher</name><affiliation wicri:level="3"><nlm:affiliation>Normandie Univ, ULH, CNRS, URCOM, 76600 Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie Univ, ULH, CNRS, URCOM, 76600 Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Orange, Nicole" sort="Orange, Nicole" uniqKey="Orange N" first="Nicole" last="Orange">Nicole Orange</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, 55 rue saint Germain 27000 Evreux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, 55 rue saint Germain 27000 Evreux</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Evreux</settlement></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Feuilloley, Marc" sort="Feuilloley, Marc" uniqKey="Feuilloley M" first="Marc" last="Feuilloley">Marc Feuilloley</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, 55 rue saint Germain 27000 Evreux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, 55 rue saint Germain 27000 Evreux</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Evreux</settlement></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Grisel, Michel" sort="Grisel, Michel" uniqKey="Grisel M" first="Michel" last="Grisel">Michel Grisel</name><affiliation wicri:level="3"><nlm:affiliation>Normandie Univ, ULH, CNRS, URCOM, 76600 Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie Univ, ULH, CNRS, URCOM, 76600 Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27286638</idno><idno type="pmid">27286638</idno><idno type="doi">10.1016/j.ijpharm.2016.06.014</idno><idno type="wicri:Area/PubMed/Corpus">000017</idno><idno type="wicri:Area/PubMed/Curation">000017</idno><idno type="wicri:Area/PubMed/Checkpoint">000017</idno><idno type="wicri:Area/Ncbi/Merge">000550</idno><idno type="wicri:Area/Ncbi/Curation">000550</idno><idno type="wicri:Area/Ncbi/Checkpoint">000550</idno><idno type="wicri:Area/Main/Merge">000072</idno><idno type="wicri:Area/Main/Curation">000073</idno><idno type="wicri:Area/Main/Exploration">000073</idno><idno type="wicri:Area/France/Extraction">000071</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Development of preservative-free nanoparticles-based emulsions: Effects of NP surface properties and sterilization process.</title><author><name sortKey="Rowenczyk, Laura" sort="Rowenczyk, Laura" uniqKey="Rowenczyk L" first="Laura" last="Rowenczyk">Laura Rowenczyk</name><affiliation wicri:level="3"><nlm:affiliation>Normandie Univ, ULH, CNRS, URCOM, 76600 Le Havre, France; Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, 55 rue saint Germain 27000 Evreux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie Univ, ULH, CNRS, URCOM, 76600 Le Havre, France; Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, 55 rue saint Germain 27000 Evreux</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Evreux</settlement></placeName></affiliation></author><author><name sortKey="Picard, Celine" sort="Picard, Celine" uniqKey="Picard C" first="Céline" last="Picard">Céline Picard</name><affiliation wicri:level="3"><nlm:affiliation>Normandie Univ, ULH, CNRS, URCOM, 76600 Le Havre, France. Electronic address: celine.picard@univ-lehavre.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie Univ, ULH, CNRS, URCOM, 76600 Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Duclairoir Poc, Cecile" sort="Duclairoir Poc, Cecile" uniqKey="Duclairoir Poc C" first="Cécile" last="Duclairoir-Poc">Cécile Duclairoir-Poc</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, 55 rue saint Germain 27000 Evreux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, 55 rue saint Germain 27000 Evreux</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Evreux</settlement></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Hucher, Nicolas" sort="Hucher, Nicolas" uniqKey="Hucher N" first="Nicolas" last="Hucher">Nicolas Hucher</name><affiliation wicri:level="3"><nlm:affiliation>Normandie Univ, ULH, CNRS, URCOM, 76600 Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie Univ, ULH, CNRS, URCOM, 76600 Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author><author><name sortKey="Orange, Nicole" sort="Orange, Nicole" uniqKey="Orange N" first="Nicole" last="Orange">Nicole Orange</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, 55 rue saint Germain 27000 Evreux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, 55 rue saint Germain 27000 Evreux</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Evreux</settlement></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Feuilloley, Marc" sort="Feuilloley, Marc" uniqKey="Feuilloley M" first="Marc" last="Feuilloley">Marc Feuilloley</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, 55 rue saint Germain 27000 Evreux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Microbiologie Signaux et Microenvironnement EA 4312, Université de Rouen, 55 rue saint Germain 27000 Evreux</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Evreux</settlement></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Grisel, Michel" sort="Grisel, Michel" uniqKey="Grisel M" first="Michel" last="Grisel">Michel Grisel</name><affiliation wicri:level="3"><nlm:affiliation>Normandie Univ, ULH, CNRS, URCOM, 76600 Le Havre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie Univ, ULH, CNRS, URCOM, 76600 Le Havre</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Le Havre</settlement></placeName></affiliation></author></analytic><series><title level="j">International journal of pharmaceutics</title><idno type="eISSN">1873-3476</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Model emulsions were developed with or without commercial titanium dioxide nanoparticles (NP) carrying various surface treatments in order to get close physicochemical properties whatever the NP surface polarity (hydrophilic and hydrophobic). Rheology and texturometry highlighted that the macroscopic properties of the three formulated emulsions were similar. However, characterizations by optical microscopy, static light scattering and zetametry showed that their microstructures reflected the diversity of the incorporated NP surface properties. In order to use these model emulsions as tools for biological evaluations of the NP in use, they had to show the lowest initial microbiological charge and, specifically for the NP-free emulsion, the lowest bactericidal effect. Hence, formulae were developed preservative-free and a thermal sterilization step was conducted. Efficiency of the sterilization and its impact on the emulsion integrity were monitored. Results highlighted the effect of the NP surface properties: only the control emulsion and the emulsion containing hydrophilic NP fulfilled both requirements. To ensure the usability of these model emulsions as tools to evaluate the 'NP effect' on representative bacteria of the skin microflora (S. aureus and P. fluorescens), impact on the bacterial growth was measured on voluntary inoculated formulae.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Evreux</li><li>Le Havre</li></settlement><orgName><li>Université de Rouen</li></orgName></list><tree><country name="France"><region name="Région Normandie"><name sortKey="Rowenczyk, Laura" sort="Rowenczyk, Laura" uniqKey="Rowenczyk L" first="Laura" last="Rowenczyk">Laura Rowenczyk</name></region><name sortKey="Duclairoir Poc, Cecile" sort="Duclairoir Poc, Cecile" uniqKey="Duclairoir Poc C" first="Cécile" last="Duclairoir-Poc">Cécile Duclairoir-Poc</name><name sortKey="Feuilloley, Marc" sort="Feuilloley, Marc" uniqKey="Feuilloley M" first="Marc" last="Feuilloley">Marc Feuilloley</name><name sortKey="Grisel, Michel" sort="Grisel, Michel" uniqKey="Grisel M" first="Michel" last="Grisel">Michel Grisel</name><name sortKey="Hucher, Nicolas" sort="Hucher, Nicolas" uniqKey="Hucher N" first="Nicolas" last="Hucher">Nicolas Hucher</name><name sortKey="Orange, Nicole" sort="Orange, Nicole" uniqKey="Orange N" first="Nicole" last="Orange">Nicole Orange</name><name sortKey="Picard, Celine" sort="Picard, Celine" uniqKey="Picard C" first="Céline" last="Picard">Céline Picard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000071 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000071 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/France
|area= LeHavreV1
|flux= France
|étape= Analysis
|type= RBID
|clé= pubmed:27286638
|texte= Development of preservative-free nanoparticles-based emulsions: Effects of NP surface properties and sterilization process.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i -Sk "pubmed:27286638" \
| HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a LeHavreV1
| This area was generated with Dilib version V0.6.25. |  |